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Manufacturing companies face the challenge of delivering high quality products of increasing complexity, with limited use and waste of resources. "Zero Defect Manufacturing” (ZDM) is a recent paradigm aiming at going beyond traditional six-sigma approaches. The aim of the ForZDM project is to develop and demonstrate tools to support the rapid deployment of ZDM solutions in the industry and to design more competitive and robust multi-stage manufacturing systems. The ForZDM methodology expands current single process boundaries towards a production line perspective, which allows to contrast defects before, during and after their generation through diagnosis, preventive and corrective mechanisms, applied with real-time, medium term and long term control actions.